Labels & Publications

Labels

ECVAM KaLy-Cell
is inscribed on the CEI List OJ ref.:2006/S46-047741 of 09/03/2006 “Validation of Alternative Test Methods subdivided into 20 sub-fields” as one of potential service providers of the ECVAM Unit.
EU KaLy-Cell
is a partner of the EC FP7 Health - 2007-A grant n° 202222 - Predict-IV – Profiling the toxicity of new drugs: A non-animal-based approach integrating toxicodynamics and biokinetics.
EU KaLy-Cell
is leading the HepaTTox-Cell R&D project, involving the Universities of Strasbourg and Franche-Comté - Certified by the Alsace BioValley competitiveness cluster and supported by the Alsace & Franche-Comté Regions and Oséo - Human hepatocyte populations derived from adult liver stem cells for in vitro hepatotoxicity measurements and hepatocyte therapy.


Publications

  • C. Abadie, H. Martin, N. Blanchard, D. Pekthong, P. Bachellier, G. Mantion, B. Heyd, F. Schuler, P. Coassolo, E. Alexandre and L. Richert. Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicology in Vitro, 24: 346-356, 2010 View the publication

    KaLy-Cell Université de Franche-Comté Roche
  • L. Richert, C. Abadie, A. Bonet, B. Heyd, G. Mantion, E. Alexandre, P. Bachellier, S. Kingston, C. Pattenden, S. Illouz, A. Dennison, S. Hoffmann and S. Coecke. Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers – A European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study. Toxicology in Vitro, 24: 335-345, 2010 View the publication

    KaLy-Cell EU
  • M. Alvergnas, L. Richert, N. Blanchard, C. Abadie, B. Heyd, G. Mantion, Gallemann D., H. Martin. Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine. Toxicology in Vitro, 23 : 1259-1267, 2009 View the publication

    KaLy-Cell Université de Franche-Comté Merck Serono
  • L Richert, G Tuschl, C Abadie, N Blanchard, D Pekthong, G Mantion, JC Weber, SO Mueller. Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol. Appl. Pharmacol. 235:86-96, 2009. View the publication

    KaLy-Cell Merck Serono
  • RY Lin, JH Wang, XM Lu, XT Zhou, G Mantion, H Wen, DA Vuitton, L Richert. Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode. World J. Gastroenterol. 15:2116-24, 2009. View the publication

    KaLy-Cell Université de Franche-Comté
  • D Pekthong, N Blanchard, C Abadie, A Bonet, B Heyd, G Mantion, A Berthelot, L Richert, H Martin. Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chem. Biol. Interact. 179: 247-55, 2009. View the publication

    KaLy-Cell Université de Franche-Comté
  • I. Vidal, N. Blanchard, E. Alexandre, A. Gandillet, MP Chenard-Neu, F Staedtler, M Schumacher, P Bachellier, D Jaeck, H Firat, B Heyd, L Richert. Improved xenogenic hepatocyte implantation into nude mouse liver parenchyma with acute liver failure when followed by repeated anti-Fas antibody (Jo2) treatment. Cell Transplantation 17: 507-524, 2008 View the publication

    KaLy-Cell Fondation Transplantation
  • S. Illouz, E. Alexandre, C. Pattenden, L. Mark, P. Bachellier, M. Webb, D. Berry, A. Dennison, L. Richert. Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother. Res. 22: 1688-1691, 2008. View the publication

    KaLy-Cell Leicester Hospital
  • L. Richert, G. Tuschl, C. Abadie, N. Blanchard, A. Bonet, B. Heyd, N. Halkic, E Wimmer, H. Dolgos, S. Mueller. Species differences in the response of liver drug metabolizing enzymes to EMD 392949 in vivo and in vitro. Drug Metab. Dispos. 36 : 702-714, 2008 View the publication

    KaLy-Cell Merck Serono
  • D Pekthong, H Martin, C Abadie, A Bonet, B Heyd, G Mantion and L Richert. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J. Ethnopharmacol. 115: 432-40, 2008 View the publication

    KaLy-Cell Université de Franche-Comté
  • H.Martin, F. Staedtler, C. Lamboley, M. Adrian, MM Schumacher, SD Chibout, P Laurant, L Richert and A Berthelot. Effects of long-term dietary intake of magnesium on rat liver transcriptome. Magnes. Res. 20 : 259-265, 2007. View the publication

    KaLy-Cell Novartis
  • A Chlouchi, C Girard, A Bonet, C Viollon-Abadie, B Heyd , G Mantion, H Martin and L Richert. Effect of chrysin and natural coumarins, on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture. Planta Med. 73: 742-747, 2007. View the publication

    KaLy-Cell Université de Franche-Comté
  • G. Elaut, G. Laus, E. Alexandre, L. Richert, P. Bachellier, D. Tourwe, V. Rogiers and T. Vanhaecke. A metabolic screening study of trichostatin A (TSA° and TSA-like histone deacetylase inhibitors in rat an human primary cultures. Pharmacol. Exp. Therap. 321: 400-408 2007. View the publication

    KaLy-Cell University of Brussels
  • H. Martin, C. Abadie, B. Heyd, G. Mantion, L. Richert and A. Berthelot. N-acetylcysteine partially reverses oxidative stress and apoptosis exacerbated by Mg-deficiency culturing conditions in primary cultures of rat and human hepatocytes. Journal of the American College of Nutrition 25: 363-369 2006. View the publication

    KaLy-Cell Université de Franche-Comté
  • D. Jouin, N. Blanchard, F. Delobel, P. David – Pierson, T. Lavé, D. Jaeck, L. Richert and P. Coassolo Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance. Eur. J. Pharm. Biopharm. 63:347-55, 2006 View the publication

    KaLy-Cell Roche
  • L. Richert, M. J. Liguori , C. Viollon-Abadie, N. Halkic, B. Heyd, G. Mantion, and J. F. Waring.Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation but is strongly changed after hepatocyte plating. Drug Metab. Dispos. 34: 870 - 879, 2006 View the publication

    KaLy-Cell Abbot
  • A. Gandillet, I. Vidal, E. Alexandre, M. Audet, M.P. Chenard-Neu, J. Stutzmann, B. Heyd, D. Jaeck and L. Richert. Experimental models of acute and chronic liver failure in Nude mice to study hepatocyte transplantation. Cell Transplantation 14: 277 – 290, 2005. View the publication

    KaLy-Cell Fondation Transplantation
  • N. Blanchard, E. Alexandre, C. Abadie, T. Lave, B. Heyd, G. Mantion, D. Jaeck, L. Richert and P. Coassolo. Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes. Xenobiotica 35: 1-15, 2005. View the publication

    KaLy-Cell Roche
  • E.L. LeCluyse, E. Alexandre, G.A.Hamilton, C. Viollon-Abadie, D.J. Coon, S. Jolley and L. Richert. Isolation and culture of primary human hepatocytes Methods Mol. Biol. 290: 207-30, 2005 View the publication

    KaLy-Cell CellzDirect
  • N. Blanchard, L. Richert, P. Coassolo, T. Lave.Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration. Curr. Drug Metab. 5: 147-156, 2004. View the publication

    KaLy-Cell Roche
  • N. Blanchard, L. Richert, B. Notter, F. Delobel, P. David, P. Coassolo and T. Lave Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes. Eur. J. Pharm. Sci. 23:189-199, 2004. View the publication

    KaLy-Cell Roche
  • B. Refouvelet, C. Guyon, Y. Jacquot, C. Girard, H. Fein, F. Bevalot, J.F. Robert, B. Heyd, G. Mantion, L. Richert and A. Xicluna. Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture. Eur. J. Med. Chem. 39: 931-937, 2004. View the publication

    KaLy-Cell Université de Franche-Comté
  • L. Richert, E. Alexandre, T. Llyod, S. Orr, C. Viollon-Abadie, R. Patel, S. Kingston, D. Berry, B. Heyd, G. Mantion and D. Jaeck. Tissue collection, transport and isolation procedures required to optimise human hepatocyte isolation from waste liver surgical resections. A multi-laboratory study. Liver International 24: 371-378, 2004. View the publication

    KaLy-Cell Université de Franche-Comté Fondation Transplantation
  • A. Gandillet, E. Alexandre, C. Royer, J. Cinqualbre, D. Jaeck and L. Richert. Hepatocyte ploidy in regenerating livers after partial hepatectomy, drug-induced necrosis and cirrhosis. ur. Surg. Res. 35: 148-160, 2003. View the publication

    Fondation Transplantation
  • A. Gandillet, E. Alexandre, V. Holl, C. Royer, P. Bischoff, J. Cinqualbre, P. Wolf, D. Jaeck and L. Richert. Hepatocyte ploidy in normal young rat. Comp. Biochem. Physiol. part A 134: 665-673, 2003. View the publication

    Fondation Transplantation
  • D. Binda, D. Lasserre-Bigot, A. Bonet, M. Thomassin, MP Come, C. Guinchard, R. Bars, A. Jacqueson and L. Richert. Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: effect of L-NAME. Toxicology In Vitro. 17:59-67, 2003. View the publication

    Université de Franche-Comté Bayer CropScience.jpg
  • H. Martin, L. Richert, A. Berthelot. Magnesium deficiency induces apoptosis in primary cultures of rat hepatocytes. J. Nutr.133: 2505-2511, 2003. View the publication

    Université de Franche-Comté
  • L. Richert, C. Lamboley, C. Viollon-Abadie, P. Grass, N. Hartmann, S. Laurent, B. Heyd, G. Mantion, S.D. Chibout and F. Staedtler. Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes. Toxicol. Appl. Pharmacol. 191: 130-146, 2003. View the publication

    Université de Franche-Comté Novartis
  • cirrhosis induction by thioacetamide in Nagase analbuminemic rats. Lab. Anim. 36: 158-64, 2002. View the publication

    Fondation Transplantation
  • Alexandre, M. Cahn, C. Viollon-Abadie, N. Meyer, B. Heyd, G. Mantion, J. Cinqualbre, P. David, D. Jaeck and L. Richert. Influence of pre-, intra- and post-operative parameters of donor liver on the outcome of isolated human hepatocytes. Cell and Tissue Banking 3: 223-233, 2002. View the publication

    Université de Franche-Comté Fondation Transplantation
  • E. Alexandre, C. Viollon-Abadie, P. David, P. Coassolo, B. Heyd, G. Mantion, P. Wolf, P. Bachellier, D. Jaeck and Richert, L. Cryopreservation of adult human hepatocytes obtained from resected liver biopsies. Cryobiology 44:103-113, 2002. View the publication

    Université de Franche-Comté Fondation Transplantation
  • L. Richert, D. Binda, G. Hamilton, C. Viollon-Abadie, E. Alexandre, D. Bigot-Lasserre, R. Bars, P.Coassolo and E. LeCluyse. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicology in Vitro 16: 89-99, 2002. View the publication

    Université de Franche-Comté Roche
  • V. Kaulek, P. Saas, E. Alexandre, H. Grant, L. Richert, D. Jaeck, P. Tiberghien, P. Wolf and A. Azimzadeh. Comparative phenotype and immunogenicity of freshly isolated and immortalized rat hepatocytes. Cell Transplantation 10 : 739-747, 2001. View the publication

    Fondation Transplantation
  • P. David, E. Alexandre, M.P. Chenard-Neu, M. Audet, P. Wolf, D. Jaeck, A. Azimzadeh and L. Richert. Engrafment and albumin production of intrasplenically transplanted rat hepatocytes (Sprague-Dawley), freshly isolated versus cryopreserved, into Nagaze analbuminemic rats (NAR). Cell Transplantation 10 : 67-80, 2001. View the publication

    Fondation Transplantation
  • M. Colombain, V. Goll, F. Muyard, C. Girard, F. Bévalot and L. Richert. A bioassay using hepatoma cell line hepG2 for detecting phototoxicity of furocoumarins. Planta Med. 67: 644-646, 2001. View the publication

    Université de Franche-Comté
  • D. Binda, L. Nicod, C. Viollon-Abadie, A. Berthelot, P. Coassolo and L. Richert. Strain difference (WKY,SPRD) in the hepatic antioxidant status in rat and effect of hypertension (SHR,DOCA). Ex vivo and in vitro data. Mol. Cell. Biochem. 218: 139-146, 2001. View the publication

    Université de Franche-Comté Roche
  • C. Viollon-Abadie, D. Bigot-Lassčre, L. Nicod, N. Carmichael and L. Richert. Effects of model inducers on thyroxine UDP-glucuronosyl transferase activity in vitro in rat and mouse hepatocyte cultures. Toxicology in Vitro 14: 505-512, 2000. View the publication

    Université de Franche-Comté Bayer CropScience.jpg
  • V. Goll, C. Viollon-Abadie, L. Nicod and L. Richert. Peroxisome proliferators induce apoptosis and decrease DNA synthesis in rat FaO and human HepG2 hepatoma cell lines. Hum. Exp. Toxicol. 19: 193-202, 2000. View the publication

    Université de Franche-Comté
  • V. Goll, E. Alexandre, C. Viollon-Abadie, L. Nicod, D. Jaeck and L. Richert. Comparison of the effect of various peroxisome proliferators on peroxisomal enzyme activities, cell proliferation and apoptosis in rat and human hepatocyte cultures. Toxicol. Appl. Pharmacol.160: 21-32, 1999. View the publication

    Fondation Transplantation Université de Franche-Comté
  • E. Alexandre, P. David, C. Viollon-Abadie, A. Azimzadeh, P. Wolf, D. Jaeck, L. Nicod, K. Boudjema and L. Richert Variation in cytochrome P450-dependent monooxygenase activities and their response to inducing agents during the growth of human HepG2 hepatoma cells. Toxicology in Vitro 13: 427-435, 1999. View the publication

    Fondation Transplantation Université de Franche-Comté
 
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